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Oct
12
2016

FFPE or Flash Frozen? Working with Human Biospecimens In Research

By Samantha Bussell
It’s imperative in clinical trials, exploratory studies, proof of concept analysis, and research & development to attain samples which are best suited for desired outcomes. Both processing types preserve specimens well, but which to leverage is contingent upon intended application.
Oct
06
2016

MicroRNA Analysis in KRAS-Driven Tumor Growth

By Samantha Bussell
Research has found that KRAS mutations are present in 30 percent of non-small cell lung cancers (NSLC) and in 40 to 50 percent of colorectal cancers. This mutation prevalence has been linked to poor survival rates and chemotherapy resistance within the impacted oncology cohorts. In an attempt to remedy this known issue, researchers at University of California, San Diego screened KRAS mutant cells for synthetic lethal interactions (https://www.genomeweb.com/cancer/kras-driven-tumor-growth-inhibited-microrna). Results concluded that the miR-1298 gene when inhibited is lethal to the growth of KRAS-mutated cells, both in vitro and in vivo through a combination of microarray analyses.
Sep
23
2016

Tissue Vulnerability and Protein Characterization in Alzheimer’s Disease

By Samantha Bussell
Alzheimer’s disease (AD) – the most common form of dementia – is characterized by the aggregation of amyloid β (Aβ), tau in amyloid plaques, and neurofibrillary tangles that spread progressively across brain tissues. However, the mechanisms that govern selective vulnerability of specified tissues is widely debated.
Aug
31
2016

Mutation Analysis in Cancer Research

By Samantha Bussell
At BioIVT, we understand the importance of mutation analysis in cancer research. Our scientists routinely perform DNA and RNA isolation from both FFPE and Fresh Frozen tissues, as well as biofluids. Additionally, we utilize PCR and FISH for the determining the presence and/or location of particular mutations within tissue specimens. Standard mutation analysis is available for lung, skin, and colon cancers, with custom mutation screens available upon request.
Aug
15
2016

Leveraging Human Tissue for Cell Type Conversation

By Lauren Vagnone
Direct reprogramming of somatic cells has tremendous potential to advance applications in disease modeling, drug discovery, and gene and cell therapies. A study conducted by Duke University which depicts the plasticity of cells and their ability to “reprogram” for differing functions.

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