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Tissue Vulnerability and Protein Characterization in Alzheimer’s Disease

By Samantha Bussell / Sep 23, 2016

Alzheimer’s disease (AD) – the most common form of dementia – is characterized by the aggregation of amyloid β (Aβ), tau in amyloid plaques, and neurofibrillary tangles that spread progressively across brain tissues. However, the mechanisms that govern selective vulnerability of specified tissues is widely debated.

In a recent study conducted by the University of Cambridge, researchers evaluated the protein expression signatures susceptible to aggregation in AD ( By performing a transcriptome-wide microarray analysis of more than 500 healthy brain tissues and characterization using Braak staging, a vulnerability score was developed. Researchers noted that brain regions where AD is typically first noticed had elevated expression levels of proteins that co-aggregate in plaques and tangles.

BioIVT offers a variety of custom research services (including immunohistochemical and in situ hybridization microarray analysis) through our team of PHASEZERO scientists. Importantly, we manage our own tissue network, have a team of board-certified pathologists, and have over 20 years of experience in various molecular biology techniques. Thus, we are able to provide clients with the assurance that their client-tailored studies are performed via the same processes as our GLP-based studies and that well-characterized tissues of the highest quality are utilized.

For more information on how we can help you with your research needs, please feel free to contact us.

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