BioIVT Blog

    Hepatopac Model: The Truth Revealed

    By Onyi Irrechukwu, Ph.D. Sep 04, 2018
    The HEPATOPAC® model is a bioengineered, in vitro co-culture of primary hepatocytes and 3T3 murine fibroblasts. The cultures are arranged into a precise cyto-architecture that optimizes liver-specific functions and extends hepatocyte viability for several weeks, mimicking the in vivo liver. HEPATOPAC cultures secrete albumin, synthesize urea, display functional bile canaliculi, and metabolize compounds using active Phase I and Phase II enzymes at higher levels than other in vitro liver models.  Read More >

    The Microbiome: Collection Matters

    By Cathie Miller, Ph.D. Aug 22, 2018
    Why Study the Microbiome? The Microbiome has a growing importance in general health, and even more significantly, there is a growing understanding regarding the impact that an individual’s microbiome has on contributing to the cause of disease, influencing disease severity, and affecting a person’s response to medication and treatment. For example, it is now known that an individual’s microbiome affects their ability to manage their weight, is implicated in the development of arthritis, and has a role in various neuropsychiatric illnesses such as autism, schizophrenia, OCD, ADHD, and chronic fatigue syndrome. Furthermore, by comparing patients with the same disease, it has been shown that an individual’s microbiome affects the disease severity of autoimmune disorders, asthma, and infections. Perhaps even more interesting and more relevant is that an individual’s microbiome affects their response to medication including vaccination, through effects on metabolism, efficacy, and toxicity. Read More >

    How Tissue Fixation Affects Your Downstream Analysis

    By Cathie Miller, Ph.D. Aug 14, 2018
    Biospecimens are commonly used in research, from the bench through to late phase clinical trials. Understanding how pre-analytical deviations in collection, processing, and storage are critical to downstream applications and data analysis. In this post, our Director of Product Marketing for Disease State Products, Cathie Miller, Ph.D., interviewed Jason Adams, BS HTL (ASCP), BioIVT’s lead histologist to better understand how processing occurs and how it can affect the specimens. Read More >

    North American ISSX Meeting Wrap Up

    By Lauren Vagnone Jul 26, 2018
    The 22nd North American ISSX meeting was held this year in Montreal where scientists joined together to discuss issues in drug development.  Hot topics included transporters, pharmacogenomics, and antibody drug conjugates (ADCs).  The transporter session included lectures on kidney and hepatic transporters and potential association with drug-induced liver injury (DILI). Read More >

    Cell-based Assays: A Crucial Component of the Drug Discovery Process

    By Alesha Grant, Ph.D. Jul 20, 2018
    Why Utilize Cell-based Assays? Read More >

    What Really is a Buffy Coat?

    By Wini Luty Jul 03, 2018
    The definition of a buffy coat often depends on who you ask.  Buffy coat from a research lab processing point of view is a different product than buffy coat produced from a blood bank or donor center. Read More >

    AACR 2018 – Hot Topics

    By Cathie Miller, Ph.D. Jun 12, 2018
    At this year’s 110th AACR, Immuno-oncology was the topic of many discussions including seven out of eleven plenary sessions. Biggest of all was the lung cancer plenary session that discussed potentially standard-of-care-changing results from Merck, BMS, and Roche in relation to PD-L1 biomarker-related first-line treatment of metastatic non-small cell lung cancer. Read More >

    Tissue Cross Reactivity Studies for IND/CTA Submission : Tips & Issues To Consider

    By Julia Stevens, Ph.D. May 15, 2018
    Why are Tissue Cross-Reactivity Studies Needed? Read More >

    Human Primary Keratinocytes in Drug Metabolism Studies

    By Roberto Tolando, Ph.D. May 08, 2018
    Skin is the largest organ and represents the body’s protective surface as the first contact site for topically applied substances. It plays a key role in controlling not only the penetration and distribution but also the metabolism of topically applied chemicals and is thus a first pass organ for penetrating substances. Read More >

    For the Rapid Route to Quantitative Gene Expression Data, Take the XPRESSWAY™

    By Paul Murdock, Ph.D. Apr 11, 2018
    It has been said that gene expression researchers measure messenger RNA (mRNA) because they can and not because they want to.  Somewhat controversial perhaps, but the thought behind this is that measuring specific proteins and particularly functionally-active protein is all-important.  However, the reality is that measuring functional protein activity requires a bespoke assay while measuring specific proteins invariably requires the use of antibodies.  For new protein variants, antibodies are often unavailable, and even if they are, gene expression researchers have long-realized that antibodies frequently underperform in the lab.  Embarking on the process of generating an antibody or a functional assay for a new protein variant is therefore not always straightforward. Read More >

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