---
title: BioIVT Blog | Toxicity
description: Toxicity | Learn valuable insights from the world of biotechnology and pharmaceutical research.
---

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## [![shutterstock_522829429-599x400](https://blog.bioivt.com/hs-fs/hubfs/shutterstock_522829429-599x400.jpg?width=875&name=shutterstock_522829429-599x400.jpg) May 08 2018 Human Primary Keratinocytes in Drug Metabolism Studies By Roberto Tolando, Ph.D. Skin is the largest organ and represents the body’s protective surface as the first contact site for topically applied substances. It plays a key role in controlling not only the penetration and distribution but also the metabolism of topically applied chemicals and is thus a first pass organ for penetrating substances.](https://blog.bioivt.com/human-primary-keratinocytes-drug-metabolism-studies)

## [![](https://blog.bioivt.com/hs-fs/hubfs/Imported_Blog_Media/81717-e1518818607817.jpg?width=875&name=81717-e1518818607817.jpg) Aug 17 2017 Skin-derived Primary Cells and Their Uses for Cosmetic Research By Joshua Taylor Human skin tissue acts as the first line of defense against outside stimuli attempting to enter the body. It also provides an important role in maintaining an ongoing level of internal homeostasis. Separated into the Epidermis, Dermis, and Hypodermis, each layer performs a specific function essential to the maintenance of ongoing bodily function.](https://blog.bioivt.com/skin-derived-primary-cells-uses-cosmetic-research)

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