Immune cell analysis has become a heightened priority in the development of novel therapeutic medicines. The complexity of cell interactions makes evaluation inherently difficult, requiring in vitro analysis of each cell type. There have been significant strides in research to support large-scale immune interaction of various cells such as CTen (Cell Type Enrichment) and GSEA (Gene Set Enrichment Analysis), however, these methods calculate enrichment scores according to the presence of a gene query over predefined gene set and don’t account for expression information as they are qualitative in nature. This tactic is beneficial for research surrounding single cell activation during treatment and isn’t necessarily representative to mixed typing from a tissue derived sample.
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