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Contact UsWith over 100 transporter assays, we at BioIVT are the industry leader in helping our clients predict pharmacokinetic effects of transporters. We use our proprietary OPTI-EXPRESSION™ Technology to create in vitro liver, kidney, intestine, and blood-brain barrier models that assess drug safety, potential DDI effects, ADME properties, and efficacy of drugs in development. We’ve applied our technology to helping our clients generate the transporter DDI data they need for an IND submission. Our OPTI-REGULATORY Panel includes the transporters recommended for evaluation by regulatory authorities including the FDA, EMA, and PMDA. OPTI-EXPRESSION Technology is uniquely suited to developing multi-transporter models that enable us to investigate interaction effects of transporters. For example, we collaborated with Incyte Corporation to develop a multi-transporter model to investigate the interaction of itacitinib (INCB039110), a Janus kinase 1 [JAK1] inhibitor under development, with five transporters that were thought to be involved in the renal clearance of creatinine. Study results were published in Y. Zhang, et al., Drug Metab Dispos 43:485–489, April 2015.
For clients who prefer to conduct studies in their own laboratories, we provide customized ready-to-use TRANSFLEX™ Plates with cells expressing transporters of interest.
Whether you need transporter research data for a regulatory submission, want to investigate the mechanistic disposition or pharmacokinetics of your compound, or are looking for novel transporter models, talk to our experienced team about designing your transporter evaluation strategy.
I have over 20 years’ experience leading transporter research and integrating transporter studies into in vitro ADME programs and IND filings. Prior to joining the team at BioIVT I led research programs at GSK, Merck, and Amgen. At Amgen, I developed higher throughput transporter tools to support early discovery and development projects in the department of Pharmacokinetics and Drug Metabolism. I have been a member of the American Association for Pharmaceutical Scientists (AAPS) since 1996 and have had the privilege of serving as the Chair of the Drug Transport Focus Group (DTFG). In that capacity I led the recent efforts to convert the DTFG to the Drug Transport Community. I have organized, moderated, and presented many AAPS symposia, workshops, and poster sessions as member of AAPS. I am the recent Chair-Elect for the Boston Society HT-ADME Steering Committee and excited to be helping to develop transporter conferences and workshops in the Boston area. My combined experiences have helped me to develop commercialization strategies for expanding our ADME-Tox services at BioIVT. We at BioIVT understand the priorities of pharmaceutical R&D, and I along with all my ADME-Tox colleagues, are dedicated to helping our clients achieve their research objectives. We look forward to hearing from you.
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