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Gene Expression and Tissue Variety Uncovers Disease Subtypes in Crohn’s Disease

By Samantha Bussell / Oct 24, 2016

It is widely accepted that the presentation and course of Crohn’s disease (CD) is highly variable. A new study conducted by the University of North Carolina at Chapel Hill and Cedars-Sinai Medical Center sought to conceptualize the cellular mechanisms behind CD and characterize the processes associated with disease phenotypes (

This was accomplished by attaining non-inflamed colon tissue from a cohort of 21 CD patients and comparing them against 11 unaffected controls. Subsequently, the tissues were analyzed for gene expression patterns by combining RNA sequencing and formaldehyde-assisted isolation of regulatory elements. Within this process, researchers found that CD may be divided into two molecular subtypes based upon colon tissue gene expression patterns. One of the inferred subtypes resembled typical colon tissue, while the other more closely clustered with tissue from the ileum.

At BIOIVT, we understand the importance of tissue variety and gene expression in research such as this. Developing therapies that are targeted to specific genetic biomarkers reduces the toxicological imprint on the target population and increases the survival rate. To support current research efforts, our scientists routinely perform RNA isolation services from both FFPE and Fresh Frozen tissues, as well as biofluids.

For more information on how we can help you with your tissue and /or mutation analysis needs, please feel free to contact us.

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