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    Onyi Irrechukwu, Ph.D.

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    Hepatopac Model: The Truth Revealed

    By Onyi Irrechukwu, Ph.D. Sep 04, 2018
    The HEPATOPAC® model is a bioengineered, in vitro co-culture of primary hepatocytes and 3T3 murine fibroblasts. The cultures are arranged into a precise cyto-architecture that optimizes liver-specific functions and extends hepatocyte viability for several weeks, mimicking the in vivo liver. HEPATOPAC cultures secrete albumin, synthesize urea, display functional bile canaliculi, and metabolize compounds using active Phase I and Phase II enzymes at higher levels than other in vitro liver models.  Read More >