BioIVT Blog

    How Do You Silence A Gene Using siRNA In HEPATOPAC® Co-Cultures?

    By Miranda Yang, PhD Sep 11, 2019
    Biologists use a variety of approaches to disable a gene in order to gain an understanding about its function. Methods to disable genes include gene-editing techniques (TALEN or CRISPR), knockout animal models and RNA interference (RNAi). Since its discovery in the late 1990s, RNAi has been proven to robustly and selectively suppress expression of target genes, which is why it has rapidly become a major tool for in vitro analysis of protein function. Read More >

    Three Species, Endless Possibilities

    By Alex Rosenberg Jul 31, 2019
    Non-human primate, mouse, canine and rat are at the top of the list for animal model products purchased by scientists and researchers worldwide. Why? Their wide breadth of applications!  In 1902 William Castle started breeding mice for genetic studies. Over time, animals have been a major part of scientific research. While originally each species had their niche research areas, developments in technology and models have allowed the cross purposing of species, leading the way to better science. Read More >

    2019 SOT 58th Annual Meeting and Tox Expo Wrap Up

    By Graham Dyck Mar 27, 2019
    The SOT 58th Annual Meeting and Tox Expo was held March 10 – 14, 2019 in Baltimore, Maryland. It was the 30th anniversary of the conference and brought together scientists from around the world to discuss latest research and methods in evaluating toxicology. Read More >

    Are You Using the Correct Cells in Your Research? Different Types of Cells and Their Research Applications

    By Alex Rosenberg Feb 27, 2019
    At BioIVT, our wide breadth of isolated cells allows us to touch many different areas of research. From oncology to autoimmune and everywhere in between, our capabilities cover a variety of disease indications and research applications. A struggle that researchers sometimes face is which cells to use in their studies and when to use them. Primary cells, dissociated tumor cells, immune cells, and cell lines all have their place in research. Some overlap but also have their own niche. Immortalized cell lines have been a popular research tool for over 50 years, and while they remain useful for researchers, advances in technology have allowed for the development of methods to isolate and culture other cell types that may be more appropriate for your research. Read More >

    Why You Need Your Tissue Specimens Board-certified Pathologist Reviewed

    You may be wondering why is it so important to have tissue biospecimens reviewed by board-certified pathologists before using them for your research experiments.  Pathologist quality control on biospecimens can assure you are analyzing the correct tissue, including the anatomic site and diagnoses. This will help ensure the validity of your data and accelerate your research to reach actionable data. Read More >

    Hepatitis B Virus: Looking for a Cure

    By Scott Heyward, MS Jan 16, 2019
    Despite effective vaccine and treatment options, the Hepatitis B Virus (HBV) remains a worldwide health concern. The World Health Organization (WHO) estimates there are 257 million infected individuals1. Chronic infection with the virus can lead to several potential complications including cirrhosis and hepatocellular carcinoma. There has been a renewed push to find a curative treatment modality to aid chronically infected individuals and mitigate long term health issues.  Read More >

    What is HLA Typing And Why You Should Have Your Cells Genotyped?

    By Alex Rosenberg Dec 06, 2018
    The human body uses Human Leukocyte Antigen (HLA) markers to identify which cells do and do not belong in your body via the recognition of antigens. Antigens are molecules capable of inducing an immune response, although not all do this. Antigens that belong in the body are recognized as ‘self’ and antigens that are not ‘self’ are recognized as ‘foreign’. As part of the Major Histocompatibility Complex (MHC), HLA proteins play an essential part in this process, making sure that cells and molecules that belong in your body are unharmed while those recognized as foreign, such as viruses, pathogens, and bacteria, are destroyed and removed Read More >

    Quintuple Model Elucidates Complex Transporter-Mediated Creatinine Renal Elimination

    By Steven Louie Nov 20, 2018
    Transporters are membrane-bound proteins that facilitate the uptake or excretion of a wide range of compounds from nutrients, such as vitamins, to xenobiotic drugs like statins. Over the past decade, the regulatory agencies have identified examples of transporter-mediated drug-drug interactions (DDIs) that change drug safety and efficacy levels. In order to reduce potential DDI risks, the FDA has issued a guidance document to assist the drug development process.1  With this enhanced scrutiny of potential transporter-mediated DDIs, drug makers have also increased their research to study the potential contributions of transporters to the pharmacokinetics of their lead compounds. For example, poor brain penetration, elevated biliary or renal elimination may be indications of transporter-mediated effects limiting systemic exposure to their intended target site. Read More >

    DTCs: Straight from the Source

    By Sean Crudgington Nov 07, 2018
    Accessing clinically relevant human samples can be a struggle for oncology researchers. The procurement of human biospecimens is strictly regulated in most clinical settings, thus preventing researchers from obtaining specific samples of interest. BioIVT’s expansive network of over 200 IRB approved collection sites facilitates the collection of a wide range of tissue and tumor types that our clients can access. Read More >

    The Rise in Respiratory Research: Increases in Disease and Illness Worldwide

    By Alex Rosenberg Sep 24, 2018
    The investment in research and development activities focused on respiratory disease coincides with the rapidly increasing incidence of respiratory disease deaths. It is crucial that researchers have access to representative models for respiratory diseases that utilize ethically collected, well-characterized human specimens and comprehensive tissue-based research services. Read More >

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