BioIVT Blog

    How Tissue Fixation Affects Your Downstream Analysis

    By Cathie Miller, Ph.D. Aug 14, 2018
    Biospecimens are commonly used in research, from the bench through to late phase clinical trials. Understanding how pre-analytical deviations in collection, processing, and storage are critical to downstream applications and data analysis. In this post, our Director of Product Marketing for Disease State Products, Cathie Miller, Ph.D., interviewed Jason Adams, BS HTL (ASCP), BioIVT’s lead histologist to better understand how processing occurs and how it can affect the specimens. Read More >

    North American ISSX Meeting Wrap Up

    By Lauren Vagnone Jul 26, 2018
    The 22nd North American ISSX meeting was held this year in Montreal where scientists joined together to discuss issues in drug development.  Hot topics included transporters, pharmacogenomics, and antibody drug conjugates (ADCs).  The transporter session included lectures on kidney and hepatic transporters and potential association with drug-induced liver injury (DILI). Read More >

    Cell-based Assays: A Crucial Component of the Drug Discovery Process

    By Alesha Grant, Ph.D. Jul 20, 2018
    Why Utilize Cell-based Assays? Read More >

    What Really is a Buffy Coat?

    By Wini Luty Jul 03, 2018
    The definition of a buffy coat often depends on who you ask.  Buffy coat from a research lab processing point of view is a different product than buffy coat produced from a blood bank or donor center. Read More >

    AACR 2018 – Hot Topics

    By Cathie Miller, Ph.D. Jun 12, 2018
    At this year’s 110th AACR, Immuno-oncology was the topic of many discussions including seven out of eleven plenary sessions. Biggest of all was the lung cancer plenary session that discussed potentially standard-of-care-changing results from Merck, BMS, and Roche in relation to PD-L1 biomarker-related first-line treatment of metastatic non-small cell lung cancer. Read More >

    Tissue Cross Reactivity Studies for IND/CTA Submission : Tips & Issues To Consider

    By Julia Stevens, Ph.D. May 15, 2018
    Why are Tissue Cross-Reactivity Studies Needed? Read More >

    Human Primary Keratinocytes in Drug Metabolism Studies

    By Roberto Tolando, Ph.D. May 08, 2018
    Skin is the largest organ and represents the body’s protective surface as the first contact site for topically applied substances. It plays a key role in controlling not only the penetration and distribution but also the metabolism of topically applied chemicals and is thus a first pass organ for penetrating substances. Read More >

    For the Rapid Route to Quantitative Gene Expression Data, Take the XPRESSWAY™

    By Paul Murdock, Ph.D. Apr 11, 2018
    It has been said that gene expression researchers measure messenger RNA (mRNA) because they can and not because they want to.  Somewhat controversial perhaps, but the thought behind this is that measuring specific proteins and particularly functionally-active protein is all-important.  However, the reality is that measuring functional protein activity requires a bespoke assay while measuring specific proteins invariably requires the use of antibodies.  For new protein variants, antibodies are often unavailable, and even if they are, gene expression researchers have long-realized that antibodies frequently underperform in the lab.  Embarking on the process of generating an antibody or a functional assay for a new protein variant is therefore not always straightforward. Read More >

    Biomarkers in Urine

    By Heather Manza Mar 29, 2018
    In 1938, it was discovered that the urine of a woman could be injected into frogs as a way to test for pregnancy (1). If the frogs laid eggs after the injection, then the woman was pregnant. The assay had a relatively quick turn-around time, was simple, and generally accurate…the principle being that the hCG hormone excreted in urine of pregnant women caused the frogs to lay eggs. However, as always, there was a better way. Read More >

    SOT 2018 Poster Session Wrap Up

    By Graham Dyck Mar 26, 2018
    We presented two posters at SOT this month in San Antonio that highlighted research performed by our Durham team. They worked with the Environmental Protection Agency (EPA) and Bristol-Myers Squibb (BMS). Read More >